A wide variety of diseases can affect the liver. Some of them are quite rare. These are some of the diseases in which the severity of liver disease may be such that a liver transplant is needed for cure :
Chronic noncholestatic liver disorders
- Chronic hepatitis C
- Chronic hepatitis B
- Autoimmune hepatitis
- Alcoholic liver disease
Cholestatic liver disorders
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Biliary atresia
- Alagille syndrome
- Nonsyndromic paucity of the intrahepatic bile ducts
- Cystic fibrosis
- Progressive familial intrahepatic cholestasis
Metabolic disorders causing cirrhosis
- Alpha-1-antitrypsin deficiency
- Wilson disease
- Nonalcoholic steatohepatitis and cryptogenic cirrhosis
- Hereditary hemochromatosis
- Tyrosinemia
- Glycogen storage disease type IV
- Neonatal hemochromatosis
Metabolic disorders causing severe extrahepatic morbidity
- Amyloidosis
- Hyperoxaluria
- Urea cycle defects
- Disorders of branch chain amino acids
Malignancies / neoplasms / cancers of the liver
- Hepatocellular carcinoma
- Hepatoblastoma
- Fibrolamellar hepatocellular carcinoma
- Hemangioendothelioma
- Cholangiocarcinomas in very selected cases
- Liver – only metastases from Colorectal cancer or Neuroendocrine tumours , in very rare cases
Acute / Fulminant hepatic failure meeting King’s College Criteria
Acute on Chronic Liver Failure ( ACLF )
Acute Alcoholic Steatohepatits
Miscellaneous conditions
These tumors develop from the hormone-producing cells and can be functioning (producing hormones) or non-functioning (not producing hormones). They are less common but can be less aggressive.
- Budd-Chiari syndrome
- Metastatic neuroendocrine tumors
- Polycystic disease replacing most of the liver
- Multiple hemangiomas replacing most of the liver